The Missouri Department of Transportation will be closing all lanes of Interstate 64 between Jefferson Avenue and Hampton Avenue starting at 8 p.m. Friday night until 5 a.m. Monday morning.
The closures are part of a 3 month project to replace the 50 year old Jefferson overpass.
Eastbound on-ramps will be closed from McCausland to Ewing, and westbound on-ramps will be closed from Broadway to Grand.
The Jefferson Bridge itself will close at 7 p.m. Friday.